Ameliorative efficacy of Sepia officinalis ink extract on hepatorenal injury-induced following high-dose folic acid supplementation in rats

Sepia ink, a black suspension of melanin granules, is multifunctional marine bioactive material. The present study aims to evaluate the ameliorative effect ink extract (IE) cuttlefish (Sepia officinalis) during high dosage administration FA in rats. Kidney injury induced by single oral dose (250 mg /kg). Eighteen male Wistar albino rats were control, group, and FA+ IE group (250mg/kg). showed significant against hepatorenal intake as evident decreasing levels serum aminotransferases (AST ALT), urea, creatinine, uric acid, significantly increased total albumin. Treatment with normalized antioxidant status injured animals reducing MDA increase GSH CAT. revealed that had an insightful injury-induced following rats, it alleviates alterations oxidative stress markers.